Melnyk O, Kuo JK, Li ZA, Jo JH, Hughes JW, Linnemann AK. (2025) Intravital imaging reveals glucose-dependent cilia movement in pancreatic islets in vivo. Metabolism.

Sviben S, Polino AJ, Melena I, Hughes JW. (2024) Immuno-Scanning Electron Microscopy of Islet Primary Cilia. J Cell Sci.

Adamson SE, Li ZA, Hughes JW. (2023) Beta cell primary cilia mediate somatostatin responsiveness via SSTR3. Islets.

Polino AJ, Sviben S, Melena I, Piston DW, Hughes JW. (2023) Scanning electron microscopy of human islet cilia. PNAS.

Chabosseau P, Yong F, Delgadillo-Silva LF, Lee EY, Melhem R, Li S, Gandhi N, Wastin J, Lopez Noriega L, Leclerc I, Ali Y, Hughes JW, Sladek R, Martinez-Sanchez A, Rutter G. (2023) Molecular phenotyping of single pancreatic islet leader beta cells using Flash-Seq. Life Sciences.

Cho JH, Li ZA, Zhu L, Muegge BD, Roseman HF, Lee EY, Utterback T, Woodhams LG, Bayly PV, Hughes JW (2022) Islet primary cilia motility controls insulin secretion. Science Advances.

Li Z, Cho JH, Woodhams L, Hughes JW. (2022) Fluorescent imaging of beta cell primary cilia. Frontiers in Endocrinology.

Hughes JW, Cho JH, Conway HE, DiGruccio MR, Ng XW, Roseman HF, Abreu D, Urano F, Piston DW. (2020) Primary cilia control glucose homeostasis via paracrine interactions. PNAS.

T1D

Autoimmune mechanisms, clinical epidemiology, and immunomodulatory therapy of type 1 diabetes.

Vomund A, Zinselmyer B, Hughes J, Calderon B, Valderrama C, Ferris S, Wan X, Kanekura K, Carrero J, Urano F, Unanue E. (2015) Beta cells transfer vesicles containing insulin to phagocytes for presentation to T cells. PNAS.

Hughes JW, Vudattu N, Sznol M, Gettinger S, Kluger H, Lupsa B, & Herold KC. (2015) Precipitation of autoimmune diabetes with anti-PD-1 immunotherapy. Diabetes Care.

Hughes JW, Riddlesworth T, Miller K, DiMeglio L, Rickels M, McGill JB, T1D Exchange Clinic Network (2016) Autoimmune diseases in children and adults with Type 1 Diabetes from the T1D exchange clinic registry. J Clin Endocrinol Metab.

Hughes JW, Hollander A, Wyckoff J, Derdeyn C, McGill JB (2016) Moyamoya disease in young women with type 1 diabetes. J Diabetes Complications.

Hughes JW, Muegge BD, Tobin GS, Litvin M, Sun L, Saenz JB, Gyawali CP, McGill JB (2017) High risk gastric pathology and prevalent autoimmune diseases in patients with pernicious anemia. Endocrine Practice.

Bao YC, Salam M, Parks D, McGill JB, Hughes JW (2018) High prevalence of systemic rheumatic diseases in women with type 1 diabetes. J Diabetes Complications.

Hughes JW, Bao Y, Salam M, Joshi P, Kilpatrick CR, Juneja K, Nieves D, Bouhairie V, Jordan OJ, Blustin EC, Tobin GS, McGill JB (2019) Late Onset T1DM and Older Age Predict Risk of Additional Autoimmune Disease. Diabetes Care.

Herold KC, Bucktrout SL, Wang X, Bode BW, Gitelman SE, Gottlieb P, Hughes JW, Joh T, McGill JB, Pettus JH, Potluri S, Schatz D, Shannon M, Udata C, Wong GY, Levisetti M, Ganguly BJ, Garzone PD, and the RN168 Working Group (2019) Immuno-modulatory activity of humanized anti–IL-7R monoclonal antibody RN168 in subjects with type 1 diabetes. JCI Insight.

Opinions & Reviews

Our thoughts on islet and cilia research.

Adamson SE & Hughes JW. (2024) Paracrine Signaling by Pancreatic Islet Cilia. Curr Opin Endo Metab Res.

Lee EY & Hughes JW. (2023) Rediscovering Primary Cilia in Pancreatic Islets. Diabetes & Metabolism Journal.

Melena I, Hughes JW. (2022) Islet cilia and glucose homeostasis. Frontiers in Cell and Developmental Biology.

Cho JH, Hughes JW. (2022) Cilia action in islets: lessons from mouse models. Frontiers in Endocrinology.

Hughes JW, Ustione A, Lavagnino Z, Piston D. (2018) Regulation of islet glucagon secretion: Beyond calcium. Diabetes, Obesity and Metabolism.

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